Assessment of Marrubium vulgare hydro-alcoholic extract’s biological activities

Authors

  • Samuel Mulondo Student
  • Afaf
  • Hayet University of Blida 1, Algeria
  • Kimbugwe University of Blida 1, Algeria

Keywords:

Marrubium vulgare, hydro-alcoholic extract, biological activities

Abstract

 Marrubium vulgare is a tall, robust herbaceous perennial plant originating from Asia and Mediterranean and currently distributed throughout North, South America, Europe, Mediterranean and west Asia.M.vulgare thrives in any type of the soil but it prefers light calcareous, dry soils where it is sunny and warm at an altitude between 1500 –2400 m. This plant is becoming increasingly important because it is currently cultivated in different countries to be used as a source of medicine and food flavors .Also,it has more than 54 different phytocompounds such as polyphenols, monoterpenes, diterpenes and essential oils. Marrubin was the first isolated diterpenes and it’s characterized as the chemotaxonomic marker for the genus Marrubium. According to different studies, these compounds are responsible for antioxidant, antimicrobial, antifungal, analgesic, and anti-inflammatory, wound healing and anthelmintic activities. Due to these biological activities, hydroalcoholic extracts of Marrubim vulgare have been exploited for their therapeutic nature by traditional healers to cure several illnesses in Algeria. This review is to assess the different studies of hydroalcoholic extracts of Marrubium vulgare for different biological activities.

Author Biographies

Afaf

Microbial Systems Research laboratory Kouba, Algeria

Hayet, University of Blida 1, Algeria

Department of cell biology and Physiology

Kimbugwe, University of Blida 1, Algeria

Department of biotechnology, University of Blida 1, Algeria

References

Aćimović, M., Jeremić, K., Salaj, N., Gavarić, N., Kiprovski, B., Sikora, V., & Zeremski, T. (2020). Marrubium vulgare L.: A Phytochemical and Pharmacological Overview. Molecules, 25(12), 2898. https://doi.org/10.3390/molecules25122898

Amel, A., & Sélima, B. (2015). Larvicidal Effect of Marrubium Vulgare on Culexpipiens in Eastern Algeria. Energy Procedia, 74, 1026–1031. https://doi.org/10.1016/j.egypro.2015.07.739

Amri, B., Martino, E., Vitulo, F., Corana, F., Kaâb, L. B.-B., Rui, M., Rossi, D., Mori, M., Rossi, S., & Collina, S. (2017). Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties. Molecules, 22(11), 1851. https://doi.org/10.3390/molecules22111851

Bouterfas, K., Mehdadi, Z., Benmansour, D., Khaled, M. B., Bouterfas, M., & Latreche, A. (2014). Optimization of Extraction Conditions of Some Phenolic Compounds from White Horehound (<i>Marrubium vulgare</i> L.) Leaves. International Journal of Organic Chemistry, 04(05), 292–308. https://doi.org/10.4236/ijoc.2014.45032

Bouterfas, K., Mehdadi, Z., Elaoufi, M. M., Aouad, L., Latreche, A., & Benchiha, W. (2018). In vitro antibacterial activity of flavonoids extracts from three Algerian horehound (Marrubium vulgare L.) leaves. Oriental Pharmacy and Experimental Medicine, 18(1), 59–66. https://doi.org/10.1007/s13596-017-0287-5

Elberry, A. A., Harraz, F. M., Ghareib, S. A., Gabr, S. A., Nagy, A. A., & Abdel-Sattar, E. (2015). Methanolic extract of Marrubium vulgare ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats. International Journal of Diabetes Mellitus, 3(1), 37–44. https://doi.org/10.1016/j.ijdm.2011.01.004

Gavarić, A., Vidović, S., Aladić, K., Jokić, S., & Vladić, J. (2021). Supercritical CO 2 extraction of Marrubium vulgare: Intensification of marrubiin. RSC Advances, 11(16), 9067–9075. https://doi.org/10.1039/D0RA10253A

Guedri Mkaddem, M., Zrig, A., Ben Abdallah, M., Romdhane, M., Okla, M., Al-Hashimi, A., Alwase, Y., Hegab, M., Madany, M., Hassan, A., Beemster, G., & AbdElgawad, H. (2022). Variation of the Chemical Composition of Essential Oils and Total Phenols Content in Natural Populations of Marrubium vulgare L. Plants, 11(5), 612. https://doi.org/10.3390/plants11050612

Hamdaoui, B., Wannes, W. A., Marrakchi, M., Brahim, N. B., & Marzouk, B. (2013). Essential Oil Composition of Two Tunisian Horehound Species: Marrubium vulgare L. and Marrubium aschersonii Magnus. Journal of Essential Oil Bearing Plants, 16(5), 608–612. https://doi.org/10.1080/0972060X.2013.854492

Karakaş, N., Karadağ, A. E., Yilmaz, R., Demi̇Rci̇, F., & Okur, M. E. (2019). In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract. Journal of Research in Pharmacy, 23(4), 711–718. https://doi.org/10.12991/jrp.2019.180

Kebbi, S., Fadel, H., Chalchat, J., Figueredo, G., Chalard, P., Hazmoune, H., Benayache, F., Benayache, S., & Seghiri, R. (2020). Chemical Composition of Algerian Thymus algeriensis Boiss. & Reut. And Marrubium vulgare L. (Lamiaceae) Essential Oils from the Aures Region. Acta Scientifica Naturalis, 7(2), 1–14. https://doi.org/10.2478/asn-2020-0016

Lodhi, S., Vadnere, G., Sharma, V., & Usman, M. (2017). Marrubium vulgare L.: A review on phytochemical and pharmacological aspects. Journal of Intercultural Ethnopharmacology, 6(4), 429. https://doi.org/10.5455/jice.20170713060840

Martino, E., Della Volpe, S., Cavalloro, V., Amri, B., Kaab, L. B. B., Marrubini, G., Rossi, D., & Collina, S. (2019). The use of a microwave‐assisted solvent extraction coupled with HPLC‐UV/PAD to assess the quality of MARRUBIUM VULGARE L. (White horehound) herbal raw material. Phytochemical Analysis, 30(4), 377–384. https://doi.org/10.1002/pca.2820

Mittal, V., & Nanda, A. (2017). Intensification of marrubiin concentration by optimization of microwave-assisted (low CO 2 yielding) extraction process for Marrubium vulgare using central composite design and antioxidant evaluation. Pharmaceutical Biology, 55(1), 1337–1347. https://doi.org/10.1080/13880209.2017.1297837

Mssillou, I., Agour, A., Hamamouch, N., Lyoussi, B., & Derwich, E. (2021). Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L. The Scientific World Journal, 2021, 1–8. https://doi.org/10.1155/2021/7011493

Mssillou, I., Agour, A., Slighoua, M., Chebaibi, M., Amrati, F. E.-Z., Alshawwa, S. Z., kamaly, O. A., El Moussaoui, A., Lyoussi, B., & Derwich, E. (2022). Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing. Pharmaceuticals, 15(3), 289. https://doi.org/10.3390/ph15030289

Özbek, O., Budak, Y., Berkel, Ç., Özyi̇Ği̇T, Ç., & Yanar, Y. (2020). The use of Marrubium vulgare L. plant extracts in the control of fungal plant pathogens. International Journal of Agriculture, Environment and Food Sciences, 476–482. https://doi.org/10.31015/jaefs.2020.4.11

Rodríguez Villanueva, J., Martín Esteban, J., & Rodríguez Villanueva, L. (2017). A Reassessment of the Marrubium Vulgare L. Herb’s Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons. Medicines, 4(3), 57. https://doi.org/10.3390/medicines4030057

Salaj, N., Barjaktarovic, J., Kladar, N., Gavaric, N., & Bozin, B. (2018). Biomedical potential of horehound extract (Marrubium vulgare, Lamiaceae). Medicinski Pregled, 71(1–2), 21–26. https://doi.org/10.2298/MPNS1802021S

Salama, M. M., Taher, E. E., & El-Bahy, M. M. (2012). Molluscicidal and Mosquitocidal Activities of the Essential oils of Thymus capitatus Hoff. Et Link. And Marrubium vulgare L. Revista Do Instituto de Medicina Tropical de São Paulo, 54(5), 281–286. https://doi.org/10.1590/S0036-46652012000500008

Yabrir, B. (2019). Essential Oil of Marrubium vulgare: Chemical Composition and Biological Activities. A Review. Natural Product Sciences, 25(2), 81. https://doi.org/10.20307/nps.2019.25.2.81

Zohuri, B. (2021). Essential Oil Composition and Antimicrobial Activities of Lavandula pubescens, Marrubium vulgare and Meriandra bengalensis from Yemen. Acta Scientific Pharmaceutical Sciences, 5(10), 50–58. https://doi.org/10.31080/ASPS.2021.05.0794

Published

2023-07-06

How to Cite

Mulondo, S., Afaf , L. ., Hayet, C., & Muzamiru, K. (2023). Assessment of Marrubium vulgare hydro-alcoholic extract’s biological activities . Algerian Journal of Biosciences, 4(01), 001–008. Retrieved from http://www.journal.acse.science/index.php/ajb/article/view/129